Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, and therapeutic potential
Identifieur interne : 001E57 ( Main/Exploration ); précédent : 001E56; suivant : 001E58Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, and therapeutic potential
Auteurs : Melissa M. Coughlin [États-Unis] ; Bellur S. Prabhakar [États-Unis]Source :
- Reviews in Medical Virology [ 1052-9276 ] ; 2012-01.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (isolement et purification), Anticorps monoclonaux (immunologie), Anticorps monoclonaux (isolement et purification), Anticorps neutralisants (immunologie), Anticorps neutralisants (isolement et purification), Antiviraux (isolement et purification), Antiviraux (pharmacologie), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (antagonistes et inhibiteurs), Glycoprotéines membranaires (immunologie), Humains, Immunothérapie (), Liaison aux protéines, Protéines de l'enveloppe virale (antagonistes et inhibiteurs), Protéines de l'enveloppe virale (immunologie), Souris, Souris transgéniques, Syndrome respiratoire aigu sévère (), Virus du SRAS (immunologie), Épitopes (immunologie).
- MESH :
- antagonistes et inhibiteurs : Glycoprotéines membranaires, Protéines de l'enveloppe virale.
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Anticorps neutralisants, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus du SRAS, Épitopes.
- isolement et purification : Anticorps antiviraux, Anticorps monoclonaux, Anticorps neutralisants, Antiviraux.
- pharmacologie : Antiviraux.
- Animaux, Glycoprotéine de spicule des coronavirus, Humains, Immunothérapie, Liaison aux protéines, Souris, Souris transgéniques, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antibodies, Monoclonal (isolation & purification), Antibodies, Neutralizing (immunology), Antibodies, Neutralizing (isolation & purification), Antibodies, Viral (immunology), Antibodies, Viral (isolation & purification), Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Epitopes (immunology), Humans, Immunotherapy (methods), Membrane Glycoproteins (antagonists & inhibitors), Membrane Glycoproteins (immunology), Mice, Mice, Transgenic, Protein Binding, SARS Virus (immunology), Severe Acute Respiratory Syndrome (therapy), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (antagonists & inhibitors), Viral Envelope Proteins (immunology).
- MESH :
- chemical , antagonists & inhibitors : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Epitopes, Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , isolation & purification : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antiviral Agents.
- chemical , pharmacology : Antiviral Agents.
- immunology : SARS Virus.
- methods : Immunotherapy.
- therapy : Severe Acute Respiratory Syndrome.
- Teeft :
- Ace2, Amino, Amino acids, Animals, Basic residues, Biological chemistry, Chain genes, Chimeric, Convalescent, Convalescent patients, Copyright, Corona, Coronavirus, Covs, Epitope, Glycoprotein, Hmab, Hmabs, Human neutralizing mabs, Humanized, Humans, Igg2, Immunoglobulin, Immunology, Infectious diseases, John wiley sons, Mabs, Mice, Mice, Transgenic, Monoclonal, Monoclonal antibodies, Mouse, Mutant, National academy, Neutralization, Neutralizing, Neutralizing hmabs, Outbreak, Palm civet, Passive immunotherapy, Peptide, Phage display, Prabhakar, Protein Binding, Pseudotyped, Pseudotyped virus, Putative fusion peptide, Receptor, Receptor binding, Receptor binding domain, Receptor binding motif, Respiratory syndrome, Respiratory syndrome corona, Respiratory syndrome coronavirus, Sars, Sars coronavirus, Sars patients, Scfv, Scfv libraries, Spike, Spike Glycoprotein, Coronavirus, Spike protein, Syndrome, Syndrome coronavirus, Transgenic, Transgenic mice, Transgenic mouse, Vaccine, Viral, Viral entry, Viral titers, Virol, Virology, Virus, Wide range, Xenomousew.
Abstract
The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS‐CoV) led to a rapid response not only to contain the outbreak but also to identify possible therapeutic interventions, including the generation of human monoclonal antibodies (hmAbs). hmAbs may be used therapeutically without the drawbacks of chimeric or animal Abs. Several different methods have been used to generate SARS‐CoV specific neutralizing hmAbs including the immunization of transgenic mice, cloning of small chain variable regions from naïve and convalescent patients, and the immortalization of convalescent B cells. Irrespective of the techniques used, the majority of hmAbs specifically reacted with the receptor binding domain (RBD) of the spike (S) protein and likely prevented receptor binding. However, several hmAbs that can bind to epitopes either within the RBD, located N terminal of the RBD or in the S2 domain, and neutralize the virus with or without inhibiting receptor binding have been identified. Therapeutic utility of hmAbs has been further elucidated through the identification of potential combinations of hmAbs that could neutralize viral variants including escape mutants selected using hmAbs. These results suggest that a cocktail of hmAbs that can bind to unique epitopes and have different mechanisms of action might be of clinical utility against SARS‐CoV infection, and indicate that a similar approach may be applied to treat other viral infections. Copyright © 2011 John Wiley & Sons, Ltd.
Url:
- https://api.istex.fr/ark:/67375/WNG-PX0JPJHV-H/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256278
DOI: 10.1002/rmv.706
Affiliations:
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Le document en format XML
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<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Neutralizing (isolation & purification)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antibodies, Viral (isolation & purification)</term>
<term>Antiviral Agents (isolation & purification)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Epitopes (immunology)</term>
<term>Humans</term>
<term>Immunotherapy (methods)</term>
<term>Membrane Glycoproteins (antagonists & inhibitors)</term>
<term>Membrane Glycoproteins (immunology)</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Protein Binding</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (therapy)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins (antagonists & inhibitors)</term>
<term>Viral Envelope Proteins (immunology)</term>
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<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps antiviraux (isolement et purification)</term>
<term>Anticorps monoclonaux (immunologie)</term>
<term>Anticorps monoclonaux (isolement et purification)</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Anticorps neutralisants (isolement et purification)</term>
<term>Antiviraux (isolement et purification)</term>
<term>Antiviraux (pharmacologie)</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires (antagonistes et inhibiteurs)</term>
<term>Glycoprotéines membranaires (immunologie)</term>
<term>Humains</term>
<term>Immunothérapie ()</term>
<term>Liaison aux protéines</term>
<term>Protéines de l'enveloppe virale (antagonistes et inhibiteurs)</term>
<term>Protéines de l'enveloppe virale (immunologie)</term>
<term>Souris</term>
<term>Souris transgéniques</term>
<term>Syndrome respiratoire aigu sévère ()</term>
<term>Virus du SRAS (immunologie)</term>
<term>Épitopes (immunologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
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<term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Epitopes</term>
<term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Antiviral Agents</term>
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<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
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<term>Anticorps monoclonaux</term>
<term>Anticorps neutralisants</term>
<term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
<term>Virus du SRAS</term>
<term>Épitopes</term>
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<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps monoclonaux</term>
<term>Anticorps neutralisants</term>
<term>Antiviraux</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunotherapy</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
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<keywords scheme="Teeft" xml:lang="en"><term>Ace2</term>
<term>Amino</term>
<term>Amino acids</term>
<term>Animals</term>
<term>Basic residues</term>
<term>Biological chemistry</term>
<term>Chain genes</term>
<term>Chimeric</term>
<term>Convalescent</term>
<term>Convalescent patients</term>
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<term>Corona</term>
<term>Coronavirus</term>
<term>Covs</term>
<term>Epitope</term>
<term>Glycoprotein</term>
<term>Hmab</term>
<term>Hmabs</term>
<term>Human neutralizing mabs</term>
<term>Humanized</term>
<term>Humans</term>
<term>Igg2</term>
<term>Immunoglobulin</term>
<term>Immunology</term>
<term>Infectious diseases</term>
<term>John wiley sons</term>
<term>Mabs</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Monoclonal</term>
<term>Monoclonal antibodies</term>
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<term>Neutralizing</term>
<term>Neutralizing hmabs</term>
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<term>Phage display</term>
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<term>Protein Binding</term>
<term>Pseudotyped</term>
<term>Pseudotyped virus</term>
<term>Putative fusion peptide</term>
<term>Receptor</term>
<term>Receptor binding</term>
<term>Receptor binding domain</term>
<term>Receptor binding motif</term>
<term>Respiratory syndrome</term>
<term>Respiratory syndrome corona</term>
<term>Respiratory syndrome coronavirus</term>
<term>Sars</term>
<term>Sars coronavirus</term>
<term>Sars patients</term>
<term>Scfv</term>
<term>Scfv libraries</term>
<term>Spike</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Spike protein</term>
<term>Syndrome</term>
<term>Syndrome coronavirus</term>
<term>Transgenic</term>
<term>Transgenic mice</term>
<term>Transgenic mouse</term>
<term>Vaccine</term>
<term>Viral</term>
<term>Viral entry</term>
<term>Viral titers</term>
<term>Virol</term>
<term>Virology</term>
<term>Virus</term>
<term>Wide range</term>
<term>Xenomousew</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Humains</term>
<term>Immunothérapie</term>
<term>Liaison aux protéines</term>
<term>Souris</term>
<term>Souris transgéniques</term>
<term>Syndrome respiratoire aigu sévère</term>
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<front><div type="abstract">The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS‐CoV) led to a rapid response not only to contain the outbreak but also to identify possible therapeutic interventions, including the generation of human monoclonal antibodies (hmAbs). hmAbs may be used therapeutically without the drawbacks of chimeric or animal Abs. Several different methods have been used to generate SARS‐CoV specific neutralizing hmAbs including the immunization of transgenic mice, cloning of small chain variable regions from naïve and convalescent patients, and the immortalization of convalescent B cells. Irrespective of the techniques used, the majority of hmAbs specifically reacted with the receptor binding domain (RBD) of the spike (S) protein and likely prevented receptor binding. However, several hmAbs that can bind to epitopes either within the RBD, located N terminal of the RBD or in the S2 domain, and neutralize the virus with or without inhibiting receptor binding have been identified. Therapeutic utility of hmAbs has been further elucidated through the identification of potential combinations of hmAbs that could neutralize viral variants including escape mutants selected using hmAbs. These results suggest that a cocktail of hmAbs that can bind to unique epitopes and have different mechanisms of action might be of clinical utility against SARS‐CoV infection, and indicate that a similar approach may be applied to treat other viral infections. Copyright © 2011 John Wiley & Sons, Ltd.</div>
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